The development of oral delivery systems for protein and peptide drugs has long been the goal of the pharmaceutical field.However,extremely low bioavailability has been an unsolved problem in this research.This is related to the physical and chemical properties of the protein and peptides,as well as the three physiological barriers:the complex pH and enzyme environment after oral administration,the mucus barrier and the intestinal epithelial tissue barrier.With its porous rigid structure and high drug loading and strong stability,inorganic particle carrier has the ability to penetrate mucus and transport intestinal epithelia after surface modification,thus overcoming the three physiological barriers.This study introduces the current clinical application of protein and peptide drugs for oral administration,and the mechanism and coping strategies of physiological barrier that limit their oral absorption.Additionally,the application of inorganic materials as carriers in the oral delivery system of protein and peptide drugs are summarized.
inorganic carriersprotein and peptide drugoral delivery
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