Research Progress of Targeted Nano-delivery System for Hepatocellular Carcinoma Based on Glycyrrhetinic Acid
Targeted nano-drug delivery system(TNDDS)offers prominent advantages in drug delivery for treatment of hepatocellu-lar carcinoma,targeting the tumor site via ligand-receptor interaction.TNDDS reduces the dosage of drug to fulfill the therapeutic index requirement,improving pharmacokinetics and biodistribution.Besides,it can sustain drug release for several days after single-dose administration.In recent years,glycyrrhetinic acid(GA)attracts much attention as a highly efficient ligand targeting to liver tumor.The superiority of GA is mainly reflected in its combination of efficient liver tumor targeting,superior anti-tumor activity and favorable biocompatibility.GA-based TNDDS to liver tumor possesses high site-specificity and therapeutic efficiency for chemotherapeutic drugs or genetic materials delivering.This paper focuses on the basic theory of GA as a ligand targeting to liver tumor and the researches advances in the development of GA-based nano-delivery systems.Through the review and summary in this paper,it is expected to sys-tematically present current progress of GA-based liver tumor TNDDS for interested researchers,and provide references for the develop-ment of new delivery systems.
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