基于中药活性成分纳米递药系统协同治疗乳腺癌的应用进展
Progress in the Application of Nano-drug Delivery System Based on Active Ingredients of Chinese Medicine for the Synergistic Treatment of Breast Cancer
张蒙蒙 1施高凡 2程静 2廖跃华 2曾冬冬2
作者信息
- 1. 上海中医药大学研究生院,上海 201203
- 2. 上海健康医学院医疗器械学院,上海 201318
- 折叠
摘要
中药活性成分在乳腺癌治疗的应用中具有极大的潜力,可以提高现有乳腺癌治疗策略的疗效.中药活性成分通过影响不同的信号通路产生不同的作用机制,增强肿瘤细胞对化学、激素或基因治疗剂等作用的敏感性,减少毒副作用或抑制抗癌药物的外排.纳米载体提供了各种优点,包括改善溶解度、增加稳定性和增强肿瘤靶向性,从而克服中药活性成分的临床应用限制.本文就中药活性成分与其他乳腺癌治疗药物的联合使用策略,如化疗药、激素、基因药物、小分子抑制剂和无机混合物等,并智能设计纳米递药体系,共递送中药活性成分和其他乳腺癌治疗药物协同治疗乳腺癌的进展进行综述.
Abstract
Active ingredients in Chinese medicine have great potential to be used in breast cancer treatment to improve the efficacy of existing breast cancer treatment strategies.By influencing different signaling pathways to produce different mechanisms of action,active ingredients in Chinese medicine enhance the sensitivity of tumor cells to the effects of chemical,hormonal or gene therapeutic agents,reduce toxic side effects or inhibit the efflux of anticancer drugs.In this paper,it is reviewed the strategies for the combination of Chinese herbal active ingredients with other breast cancer therapeutic agents,such as chemotherapeutic agents,hormones,gene agents,small molecule inhibitors and inorganic mixtures,and intelligently design nano-delivery systems to co-deliver Chinese herbal active ingredients and other breast cancer therapeutic agents for the synergistic treatment of breast cancer.Nanocarriers offer various advantages including improved solubility,increased stability and enhanced tumor targeting,thus overcoming the clinical application limitations of the active ingredients of TCM.
关键词
纳米载体/共递送/中药/协同作用/乳腺癌Key words
nanocarrier/co-delivery/traditional Chinese medicine/synergistic effect/breast cancer引用本文复制引用
基金项目
上海市自然科学基金项目资助(19ZR1474300)
上海健康医学院科研骨干学术导师制项目资助(2021-4)
出版年
2024
NETL
NSTL
万方数据