Progress in the Application of Nano-drug Delivery System Based on Active Ingredients of Chinese Medicine for the Synergistic Treatment of Breast Cancer
Active ingredients in Chinese medicine have great potential to be used in breast cancer treatment to improve the efficacy of existing breast cancer treatment strategies.By influencing different signaling pathways to produce different mechanisms of action,active ingredients in Chinese medicine enhance the sensitivity of tumor cells to the effects of chemical,hormonal or gene therapeutic agents,reduce toxic side effects or inhibit the efflux of anticancer drugs.In this paper,it is reviewed the strategies for the combination of Chinese herbal active ingredients with other breast cancer therapeutic agents,such as chemotherapeutic agents,hormones,gene agents,small molecule inhibitors and inorganic mixtures,and intelligently design nano-delivery systems to co-deliver Chinese herbal active ingredients and other breast cancer therapeutic agents for the synergistic treatment of breast cancer.Nanocarriers offer various advantages including improved solubility,increased stability and enhanced tumor targeting,thus overcoming the clinical application limitations of the active ingredients of TCM.
nanocarrierco-deliverytraditional Chinese medicinesynergistic effectbreast cancer
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