Literature Case Analysis of Remdesivir-Related Bradyarrhythmia
OBJECTIVE To explore the occurrence and characteristics of remdesivir-related bradyarrhythmia and provide refer-ences for clinical safe drug use.METHODS The case reports of remdesivir-related bradyarrhythmia published in PubMed,Embase,CNKI,Wanfang and VIP were searched from the establishment of each database to October 2023,and statistical analysis was conduc-ted on relevant information and data.RESULTS A total of 32 cases from 23 articles were identified and included in the analysis.There were 16 males(50.0％)and 14 females(43.8％),aged from 3 months to 80 years,with an average age of(43.1±23.5)years.Twenty-seven patients(84.4％)experienced bradyarrhythmia within 3 days after medication.When bradyarrhythmia occurred,the heart rate decreased by 25.0％to 76.0％from baseline,and 20 patients(62.5％)presented with severe bradyarrhythmia.After withdrawal or continuation of treatment and symptomatic management such as atropine or cardiac pacing,all patients had a good out-come except for 2 cases(6.3％)who eventually died from exacerbation of the primary disease.CONCLUSIONS Clinical monito-ring of the patient's heart rate should be strengthened during the use of remdesivir,especially in the first 3 days after medication.Once bradyarrhythmia is found,the patient's condition should be comprehensively considered to decide whether to stop remdesivir,and atro-pine or cardiac pacing can be inserted if necessary.
remdesivirbradyarrhythmiaadverse drug reactionliterature case analysis
万方数据
维普
