Research Progress on Quercetin Derivatives and Their Biological Activities
Quercetin,a natural polyphenol,is one of the most abundant flavonoids found in many plant foods.Quercetin is a natural antioxidant,which can protect cells from damage caused by free radicals.Quercetin is a lipophilic compound that can pass through the cell membrane and regulate many intracellular and extracellular signal pathways related to disease progression and chemoprevention.Quercetin has a wide range of pharmacological activities,anti-inflammatory,antibacterial,anti-cancer and prevention of cardiovascular and cerebrovascular diseases,but its low solubility and bioavailability limit its clinical application.In order to improve these drawbacks,people have carried out structural modifications on quercetin,such as modifying hydroxyl groups to generate esters or ethers,modifying carbonyl groups to generate hydrazone or carbonyl oxygen substituted products,8-substituted products,and forming complexes with metal ions.Quercetin derivatives with good solubility,high bioavailability,improved activity and enhanced anti-cancer activity were obtained by optimizing the structure of quercetin.The research progress of quercetin derivatives in recent years is reviewed to provide reference for the further development of quercetin derivatives.
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