Nebulization Characteristics Study of Houning Inhalation Solution
OBJECTIVE To investigate the nebulization characteristics of Houning inhalation solution(HNIS)in vitro and to pro-vide the reference for the clinical administration.METHODS The delivery rate(DR),delivered amount(DA)and aerodynamic parti-cle size distribution(APSD)in vitro of HNIS were determined by means of respiratory simulator and the next generation impactor(NGI)with the syringin as the indication component and compared among the different types of nebulizers,compressors,atomization modes and breathing patterns.RESULTS In the same atomization condition and under the adult breathing pattern,the DR were between 23.3-52.2 μg·min-1,the DA were between 178.8-353.2 µg and the deposition fraction in simulated throat(DFST)was about 2.1％for the jet nebulizers,the DR were between 3.2-21.2 µg·min-1,the DA were between 12.9-82.7 µg and the DFST were about 0.7％for the ultrasonic nebulizers,the DR were between 7.2-16.5 μg·min-1,the DA were between 93.5-217.2 µg and the DFST were a-bout 0.1％for the mesh nebulizers,the mass median aerodynamic diameter(MM AD)were between 2.2-3.6 µm.In the same atomi-zation condition and under the child breathing simulation,the DR were between 1.5-24.3 μg·min-1,the DA were between 26.3-215.4 µg.CONCLUSION The nebulization characteristics of HNIS are significant affected by the patterns and brands of the atomiztion equipment,suggesting that the atomization system should be selected according to the requirement in the clinical.Under the child breath-ing pattern,with the DA and DR reduced,the dosage and atomization time should be adjusted according to the age and pulmonary func-tion of the patients to ensure the safety and efficiency of clinical medication.
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