贝母类药材中农药残留检测方法及限量标准研究
Research on Pesticide Residue Detection Methods and Limit Standards in Fritillaria Medicinal Herbs
何成军 1耿昭 1钟恋 1辜冬琳 1金红宇 2王莹 2魏锋 2马双成 3杨蕾 1苟琰1
作者信息
- 1. 四川省药品检验研究院,国家药品监督管理局中成药质量评价重点实验室,工业和信息化部产业技术基础公共服务平台,成都 611731
- 2. 中国食品药品检定研究院,北京 102629
- 3. 国家药典委员会,北京 100061
- 折叠
摘要
目的 建立同时测定贝母类药材中登记农药、禁用农药和拟新增禁用农药残留检测方法并提出参考限量值.方法 采用乙腈提取、分散固相萃取净化,结合气相色谱串联质谱联用(GC-MS/MS)和液相色谱串联质谱联用(LC-MS/MS)技术建立了贝母中95种农药残留检测方法,并对70批样品进行测定.结果 按照GB 2763转化指导原则将贝母中吡虫啉和阿维菌素进行最大残留限量药品标准转化,同时提出18种拟新增禁用农药的参考限量值.结论 通过对贝母的研究,以期为中药标准的转化和禁用农药的增加提供方向和思路,同时为贝母类药材乃至其他中药的农药残留监管政策和技术发展提供参考.
Abstract
OBJECTIVE To establish a method for simultaneous determination of registered pesticides,prohibited pesticides,and proposed new prohibited pesticide residues in Fritillaria Medicinal Herbs,and propose reference limits.METHODS The detec-tion method for 95 pesticide residues in Fritillaria Medicinal Herbs was established using GC-MS/MS and LC-MS/MS.The prepared samples were extracted with acetonitrile and then purified with the QuEChERs method.A total of 70 batches of samples were detected by the established method.RESULTS According to the GB 2763 conversion guidelines,imidacloprid and avermectin in Fritillaria Medicinal Herbs should be converted to the maximum residue limit(MRL)standards.Additionally,reference limit values are proposed for the 18 prohibited pesticides that were previously suggested for addition.CONCLUSION The study of Fritillaria Medici-nal Herbs aims to offer guidance and inspiration for the transformation of traditional Chinese medicine standards and the expansion of the list of banned pesticides.It also provides a reference for the regulatory policies and technological advancements related to pesticide residue management in Fritillaria Medicinal Herbs and other traditional Chinese medicines.
关键词
贝母/中药/串联质谱法/登记农药/禁用农药/限值Key words
Fritillaria Medicinal Herbs/traditional Chinese medicine/MS/MS/registered pesticide/prohibited pesticide/limit value引用本文复制引用
出版年
2024
NETL
NSTL
万方数据