OBJECTIVE To establish a method for simultaneous determination of registered pesticides,prohibited pesticides,and proposed new prohibited pesticide residues in Fritillaria Medicinal Herbs,and propose reference limits.METHODS The detec-tion method for 95 pesticide residues in Fritillaria Medicinal Herbs was established using GC-MS/MS and LC-MS/MS.The prepared samples were extracted with acetonitrile and then purified with the QuEChERs method.A total of 70 batches of samples were detected by the established method.RESULTS According to the GB 2763 conversion guidelines,imidacloprid and avermectin in Fritillaria Medicinal Herbs should be converted to the maximum residue limit(MRL)standards.Additionally,reference limit values are proposed for the 18 prohibited pesticides that were previously suggested for addition.CONCLUSION The study of Fritillaria Medici-nal Herbs aims to offer guidance and inspiration for the transformation of traditional Chinese medicine standards and the expansion of the list of banned pesticides.It also provides a reference for the regulatory policies and technological advancements related to pesticide residue management in Fritillaria Medicinal Herbs and other traditional Chinese medicines.
Fritillaria Medicinal Herbstraditional Chinese medicineMS/MSregistered pesticideprohibited pesticidelimit value
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