Research Progress on Improving the Stability of Nanocrystals of Drugs Based on Multi-Effect Stabilizers
In recent years,in the process of drug research and development,insoluble drugs are faced with the problem of low bio-availability and poor absorption effect.Drug nanocrystals have attracted much attention due to their nano size and unique physical and chemical properties,which can effectively increase drug solubility and permeability,and have advantages such as low dosage of excipi-ents,high drug load and few adverse reactions.However,instability limits their further development.Multieffect stabilizers can signifi-cantly improve their stability through steric hindrance,electrostatic repulsion and solvation.The author reviews the main characteristics and limitations of drug nanocrystals,the classification of multi-effect stabilizers and their applications in vivo and in vitro by reviewing and sorting out relevant literature,in order to provide reference for the research and development of drug nanocrystals.
nanocrystalcrystal stabilitymulti-effect stabilizerhydrophobic drugpharmaceutical field
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