Emphasis is Placed on Pathological Evaluation of Dextran Sulfate Sodium-Induced Colitis Model
The chemically induced mouse colitis model is the most commonly used animal model for human inflammatory bowel disease,among which dextran sulfate sodium induced colitis model is the most widely used.In the preparation of a dextran sulfate induced model,different concentrations of dextran sulfate and different strains of mice showed varying degrees of lesion severity in the intestinal segments of different mice.Therefore,it is unreasonable to take a sample of a certain segment of the colon for pathological evaluation.The entire colon should be made into a"Swiss roll"and the pathological changes should be comprehensively evaluated by dividing it into upper,middle and lower segments of the colon.The anal canal lesion is severe,it should be evaluated separately.Only by comprehensively and correctly evaluating the intestinal lesion can the therapeutic effect of drugs be correctly evaluated.
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