OBJECTIVE To analyze the characteristics and drug cost of hepatoprotective drugs among outpatients in domestic hos-pitals and provide references for rational drug use.METHODS The outpatient prescription data of 119 hospitals in 9 cities from Jan-uary 2016 to December 2023 was collected,and the clinical application of hepatoprotective drugs was analyzed.RESULTS A total of 8 635 977 prescriptions from 3 194 167 patients were obtained in this study.The most frequent diagnoses of hepatoprotective drugs were hepatitis B(7.59％),liver cirrhosis(5.11％)and non-alcoholic steatohepatitis(4.53％).98.15％of prescriptions for 1-2 hepato-protective drugs are prescribed,and oral dosage forms account for 97.29％.The total drug cost of hepatoprotective drugs increased from 85.38 million yuan to 109.8 million yuan,and the average drug cost per time increased from 85.15 yuan to 95.52 yuan.The gly-cyrrhizin preparation was the most used regimen,and the polyene phosphatidylcholine+glycyrrhizin preparation was the most used regi-men.CONCLUSIONS The aggregate costs on hepatoprotective medications appears a consistent annual increase,which brings eco-nomic burden to medical insurance.This study analyzes the trend of hepatoprotective drug costs in the past 8 years,which is of great significance to the drug management of patients with liver disease.
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