Helicobacter pylori(H.pylori)is a microaerophilic,Gram-negative bacterium that colonizes the gastric mucosa and exhibits a distinctive spiral morphology.It was found to be involved in the development of diseases such as gastritis,peptic ulcers,and gastric cancer in 1982.Currently,H.pylori infection affects more than half of the global population,and the emergence of antibiotic resistance poses a significant challenge.Consequently,there is an urgent need for novel therapeutic agents capable of overcoming H.pylori resistance.This review provides a concise overview of the pathogenic mechanisms associated with H.pylori while summari-zing and discussing both approved pharmaceuticals and investigational drugs targeting this bacterium,with the aim of facilitating the advancement of subsequent therapeutic agents targeting H.pylori.
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