Preparation and Evaluation of Ozone Oil Inclusion Compound Gel
OBJECTIVE To study and evaluate the formulation and preparation process of ozone oil inclusion compound gel.METHODS Hydroxypropyl-β-cyclodextrin(HP-β-CD)was the inclusion material and Carbome-940 was the matrix to prepare the ozone oil inclusion compound gel,and its appearance,pH value,viscosity,peroxide value,moisture retention rate,rheological proper-ties,stability,bacteriostatic performance and biological safety were evaluated.RESULTS Finally,the semi solid gel with clear appear-ance,no particle feeling,uniform,fine,shiny,moderate viscosity and no greasy property was obtained.The pH value was(5.48±0.01),the viscosity was(46.78±0.18)Pa·s,and the moisture retention rates were(96.69±0.75)％,(95.84±0.44)％,and(94.12±0.89)％after 24,36,and 48 hours of storage,respectively,with good rheological properties.The stability test showed that ozone oil gel should not be stored at high temperature.The bacteriostatic results showed that the ozone oil gel had bacteriostatic effects on Staphylococcus aureus,Candida albicans and Escherichia coli.The bacteriostatic rate of Staphylococcus aureus and Escherichia coli reached more than 95％,and the bacteriostatic rate of Candida albicans reached more than 80％.The biosafety evaluation test showed that the ozone oil gel had no vaginal mucosa irritation,skin sensitization and acute systemic toxicity.CONCLUSION The process of preparing ozone oil inclusion compound gel by this method is simple,feasible and easy to operate.It has certain promotion val-ue and application prospect in drugs and cosmetics,which lays an experimental foundation for further industrial application of ozone oil.
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