Since the end of 2019,the new coronavirus swept the world,causing irreversible harm to social economy and human health,so the search for corresponding antiviral drugs has aroused wide attention.SARS-CoV-2 is mainly transmitted by droplets,and after the process of replication,transcription and translation in the host cell,the mature virus is excreted in the form of endocytosis,forming a closed loop of infection.Notably,the papain like protease(PLpro)encoded by non-structural protein 3(nsp3)plays an important role in this process.At the same time,PLpro also helps the virus evade the corresponding immune response in inflammatory reactions such as deubiquitination.Therefore,targeted inhibition of PLpro can not only block the overall replication process of the virus,but also restore the host's own immune function,so as to achieve a better anti-SARS-CoV-2 effect.In summary,based on the different structures of the compounds,this paper intends to conduct an exploratory summary of the recent studies on inhibitor targeting SARS-CoV-2 PLpro,in order to provide theoretical reference for the discovery of anti-SARS-CoV-2 drugs.
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