Ligustilide(LIG)is a phthalide compound found in Angelica sinensis(Oliv.)Diels and Ligusticum chuanxiong Hort,which has a wide range of pharmacological activities in clinical practice,including anti-inflammatory,antioxidant,analgesic,anti-tumor,neuroprotective,and vascular protective effects.However,LIG has poor stability and is easily affected by factors such as temper-ature,light,oxygen,pH value,and solvent type,leading to conformational changes.In addition,the low water solubility and low bio-availability of LIG limit its development and application in new drugs.The article reviews the research progress on natural sources,struc-tural characteristics and structural modifications,degradation and transformation mechanisms,main degradation influencing factors,stabi-lization methods and bioactivity of LIG in recent years,in order to provide reference for the further development and applications of LIG.
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