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大孔吸附树脂在生物碱纯化方面的应用

Application of Macroporous Adsorbent Resin on Purification of Alkaloid

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生物碱是许多中药的有效成分,生物活性显著,部分生物碱已经应用于临床.从天然植物中提取分离是临床使用制剂中生物碱的主要来源,其纯化方法和工艺一直是研究重点,笔者对近10年来大孔吸附树脂在纯化生物碱方面的应用进行系统综述,归纳了其中的共性规律和问题,并提出解决方法,进而为使用大孔树脂高效、高选择性地纯化生物碱提供研究思路,为工业化生产服务.
Akaloid is the effective component of many traditional Chinese medicines(TCM) with significant biological activity. Some kinds of alkaloid have been applied to clinic. Extraction and isolation from natural plants are the main sources of alkaloid in clinically used preparations, in which the methods and technology of purification process have been the focus of research. The application of macroporous adsorbent resin in the purification of alkaloids is systematically reviewed. The common rule and questions among them are concluded and the solution is given. The research thinking for the highly selective purification of alkaloid by macroporous is provided to serve the industrial production.

alkaloidmacroporous resinseparatesdeputesprogress

张慧芳、李嬛

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金华职业技术学院医学院,浙江,金华,321013

南京中医药大学·江苏省中药炮制重点实验室·国家中医药管理局中药炮制标准重点实验室,江苏,南京,210029

生物碱 大孔树脂 分离 纯化 进展

2011

中国药业
重庆市食品药品监督管理局

中国药业

CSTPCD
影响因子:1.369
ISSN:1006-4931
年,卷(期):2011.20(16)
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