Analysis on Compatibility Situation of Ambroxol Hydrochloride with Tanreqing Injection
Objective To study the mutual compatibility of ambroxol hydrochloride with Tanreqing Injection in different concentrations or different dissolvents.Methods Ambroxol hydrochloride was dissolved with 0.9％ sodium chloride as the A group,which was allocated to the high,low and medium concentration solution(At,A2,A3).Tanreqing Injection was mixed with 0.9％ sodium chloride,fructose and 5％ glucose for allocating to the B group solution,which was diluted to the high and low concentration solution respectively(B1,B2,B3,B4,Bs,B6).The A group solution was mixed with the B group solution in pairs.The changes in external appearance and pH values of the mixed solutions were observed respectively.Results The mixture of the A1 solution and the B group solution generated the brownish grey or grey white precipitation,which was fully deposited on the tube wall;the A2 and the B group solution were mixed,the brownish yellow precipitation was generated and partially deposited on the tube wall;the A3 solution mixing with the B group solution had no macroscopic precipitation,but after placing the mixed solution for 48h at ambient temperature,the precipitation was also generated.Conclusion The incompatibility of ambroxol hydrochloride with Tanreqing Injection exists in different concentrations and different dissolvents.Moreover,the high concentration of ambroxol hydrochloride is most apt to react with Tanreqing Injection to generate precipitation and the precipitation is easy to deposit.
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