铝碳酸镁片联合埃索美拉唑、莫沙必利治疗胃食管反流病63例
Analysis on Efficacy of Hydrotalcite Tablet Combined with Esomeprazole and Mosapride in Treatment of Gastroesophageal Reflux Disease in 63 Cases
肖俏霞 1尹庆和 1林冬红1
作者信息
- 1. 广东省东莞市东华医院药剂科，广东 东莞 523013
- 折叠
摘要
目的：观察铝碳酸镁片联合埃索美拉唑、莫沙必利治疗胃食管反流病的疗效和安全性。方法将125例胃食管反流病患者随机分为观察组和对照组。观察组63例给予铝碳酸镁片联合埃索美拉唑、莫沙必利治疗，对照组62例给予奥美拉唑联合莫沙必利治疗。结果两组的症状评分和内镜检查评分均有明显下降，但观察组下降更显著（ P＜0.05）。观察组的临床总有效率（96.83%）比对照组（75.81%）高（ P＜0.05）。观察组的内镜下总有效率（95.24%）比对照组的总有效率（80.64%）高（ P＜0.05）。两组的不良反应发生率比较（6.34%比6.45%）无显著性差异（ P>0.05）。结论铝碳酸镁片联合埃索美拉唑、莫沙必利治疗胃食管反流病疗效显著，安全性高，值得临床推广。
Abstract
Objective To investigate the clinical efficacy and safety of Hydrotalcite Tablet combined with esomeprazole and mosapride in the treatment of gastroesophageal reflux disease. Methods 125 patients with gastroesophageal reflux disease were randomly divided into the observation group and the control group. 63 cases in the observation group were given the therapy of Hydrotalcite Tablets combined with esomeprazole and mosapride, while 62 cases in the control group were given the therapy of omeprazole combined with mosapridel. The clinical efficacy and safety were compared between the two groups. Results The symptom scores and the endoscopic examination scores after treatment in the two groups were significantly decreased, but the decrease in the observation group was more significant. From the aspect of the clinical curative effect, the total effective rate in the observation group was 96. 83%, which was high-er than 75. 81% in the control group, the difference between the two groups had statistical significance ( P<0. 05 ) . From the aspect of the endoscopic curative effect, the total effective rate in the observation group was 95. 24%, which was higher than 80. 64% in the control group, the difference between the two groups had statistical significance ( P<0. 05 ) . The occurrence rate of adverse reactions had no statistical difference between two groups ( 6. 34% vs. 6. 45%, P>0. 05 ) . Conclusion Hydrotalcite Tablet combined with esomeprazole and mosapride is significantly effective and safe in the treatment of gastroesophageal reflux disease and deserves to be promoted in clinic.
关键词
铝碳酸镁片/埃索美拉唑/莫沙必利/胃食管反流病Key words
Hydrotalcite Tablet/esomeprazole/mosapride/gastroesophageal reflux disease引用本文复制引用
出版年
2014
国家科技期刊平台
NSTL
维普
万方数据