Clinical Study of Modified Shabanlizhong Decoction in the Treatment of Long-Lasting Nucleic Acid Test-Positive Patients Infected with Omicron Variant of SARS-CoV-2
Objective To investigate the clinical efficacy and safety of Shabanlizhong Decoction in the treatment of long-lasting nucleic acid test(NAT)-positive patients(hereinafter referred to as long-lasting positive patients)infected with Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods A total of 184 long-lasting positive patients who visited Shizishan Fangcang Hospital in the Jiangbei District,Chongqing from November 14 to December 14,2022 were selected and randomly divided into the test group and the control group by the Excel random function.Finally,169 cases were included,including 85 cases in the test group and 84 cases in the control group.The patients in the control group were treated with traditional Chinese medicine decoction protocol,on this basis,the patients in the test group were treated with modified Shabanlizhong Decoction.The patients in the two groups were treated until they tested negative for SARS-CoV-2 NAT twice with a sampling interval of 24 h.Results The total effective rate in the test group was 92.94%,which was significantly higher than 82.14%in the control group(P＜0.05).After treatment,the single scores and total score of main symptoms and secondary symptoms of the traditional Chinese medicine syndrome scale in the two groups significantly decreased(P＜0.05),and those in the test group were significantly lower than those in the control group(P＜0.05).The average time for two NATs to turn negative in the test group was significantly shorter than that in the control group(P＜0.05).There was one case of diarrhea in the control group and two cases in the test group,which improved after symptomatic treatment.Conclusion The modified Shabanlizhong Decoction has good clinical efficacy and safety in the treatment of long-lasting positive patients,which can shorten the time for nucleic acid to turn negative,and improve clinical symptoms.
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