Effect of Oxycodone Hydrochloride on Postoperative Hemodynamics and Oxidative Stress Response in Patients Undergoing Radical Tongue Cancer Surgery
Objective To investigate the effect of oxycodone hydrochloride on postoperative hemodynamics and oxidative stress response in patients undergoing radical tongue cancer surgery.Methods A total of 113 patients with tongue cancer who underwent radical surgery in the hospital from February 2021 to February 2022 were selected and randomly divided into the observation group(57 cases)and the control group(56 cases)by the random number table method.The patients in the two groups were anesthetized with sufentanil combined with midazolam for induction,and they were given dexmedetomidine combined with remifentanil for anesthesia maintenance.After surgery,the patients in the observation group were given the patient-controlled analgesia(PCA)with oxycodone hydrochloride,while the patients in the control group were given the PCA with sufentanil.Results At 2,6,and 24 h after surgery,the average arterial pressure and heart rate in the observation group were significantly lower than those in the control group(P＜0.05).During the recovery period,the serum levels of heme oxygenase(HO)-1 and superoxide dismutase(SOD)in the observation group were significantly higher than those in the control group(P＜0.05),while the level of malondialdehyde(MDA)in the observation group was significantly lower than that in the control group(P＜0.05).At the end of the surgery,the Postoperative Observers Assessment of Alertness/Sedation Scale(OAA/S)score in the observation group was significantly higher than that in the control group,while the Numerical Pain Rating Scale(NRS)score in the observation group was significantly lower than that in the control group(P＜0.05).The recovery time and incidence of adverse reactions were comparable between the two groups(P＞0.05).Conclusion Oxycodone hydrochloride can effectively relieve the postoperative pain for patients undergoing tongue cancer radical surgery,alleviate oxidative stress reactions,stabilize perioperative hemodynamic levels,and does not affect anesthesia recovery time,with high safety.
oxycodone hydrochloridetongue cancer radical surgeryhemodynamicsoxidative stress responsepostoperative analgesia
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