Efficacy and Safety of Sinupret in the Treatment of Rhinosinusitis:A Systematic Review
Objective To systematically evaluate the efficacy and safety of Sinupret Oral Drops in the treatment of rhinosinusitis.Methods The randomized controlled trials(RCTs)of Sinupret Oral Drops in the treatment of rhinosinusitis in The Cochrane Library(Issue 4,2022),PubMed,Embase,SCI,CNKI,WanFang,VIP,and CBMdisc were searched from the inception of each database to January 2023.Two researchers independently screened trials according to inclusion and exclusion criteria,evaluated the quality of final included literature according to the Cochrane quality evaluation criteria,and extracted data.RevMan 5.41 software was adopted for the Meta-analysis.Results A total of 22 RCTs were included,involving 3 747 patients.Meta-analysis results showed that Sinupret Oral Drops alone or in combination with conventional methods in the treatment of rhinosinusitis has significantly better effective rate[RR = 1.23,95%CI(1.17,1.29),P＜0.000 01],improvement scores of clinical symptoms such as main symptoms(MSSINV)score[MD =-1.26,95%CI(-1.63,-0.89),P＜0.000 01],visual analogue scale(VAS)score[MD =-1.19,95%CI(-1.87,-0.50),P = 0.000 8],sino-nasal outcome test-20(SNOT-20)score[MD =-2.16,95%CI(-2.86,-1.47),P＜0.000 01],improvement of cytokine levels including tumor necrosis factor-α[MD =-1.13,95%CI(-1.56,-0.69),P＜0.000 01],interleukin-6[MD =-0.93,95%CI(-1.09,-0.76),P＜0.000 01],C-reactive protein[MD =-1.91,95%CI(-2.14,-1.67),P＜0.000 01]than the control group.Conclusion Based on available clinical evidence,Sinupret Oral Drops have a high effective rate and safety in the treatment of rhinosinusitis,which can improve clinical symptom scores and cytokine levels in patients.
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