Research Progress on Furmonertinib in the Treatment of Non-Small Cell Lung Cancer
Objective To provide a reference for the rational application of furmonertinib in the clinical treatment of non-small cell lung cancer(NSCLC).Methods Literature related to furmonertinib in the Web of Science and PubMed databases from January 2021 to March 2023 were searched to summarize the research progress on the pharmacokinetic characteristics,clinical efficacy,and adverse drug reactions(ADRs)of furmonertinib.Results The drug metabolism of furmonertinib is related to the dosage and combination therapy.It has good efficacy and safety in the treatment of NSCLC and metastatic NSCLC with epidermal growth factor receptor(EGFR)ex20ins and T790M mutations.In addition to common ADRs such as liver function damage,diarrhea,rash,etc.,furmonertinib also has some rare ADRs such as thrombosis,coagulation dysfunction,hypertension,electrolyte disorders,urinary tract infections,gastrointestinal perforation,and cardiac function damage.Conclusion In clinical application,attention should be paid to monitoring the drug-drug interaction between furmonertinib and other combination drugs.To avoid severe ADR,some examinations such as liver and kidney function,cardiac ultrasound,coagulation function should be carried out for the patients before receiving furmonertinib treatment.
non-small cell lung cancerfurmonertinibtyrosine kinase inhibitordrug metabolismadverse drug reactions
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