Research Progress on Clinical Application of Sclerosants
Objective To provide a reference for the rational use of sclerosants in clinical practice.Methods The relevant literature and data in the PubMed,the China Biology Medicine disc,the official websites of National Medical Products Administration,Food and Drug Administration,Pharmaceuticals and Medical Devices Agency and European Medicines Agency from the inception of each database to March 2023 were searched to summarize the relevant information on the sclerosants and drugs with indication for sclerotherapy that had been launched at home and abroad.The guidelines and studies involving sclerosants and sclerotherapy in the UpToDate database and CNKI from the inception of each database to March 2023 were searched to summarize their clinical application,and the evidence-based evaluation was conducted.The relevant information on clinical trial registration of sclerosants and sclerotherapy up to March 2023 was obtained by the clinical trial registration websites of China,the European Union and the United States,and the development trend of sclerosants was analyzed.Results Sclerosants could be classified into cleaning agents,penetrating agents and chemical agents based on their mechanism.The approved indications were mainly varicose veins,vasodilation and so on.The clinical application of sclerotherapy in relevant guidelines was mostly based on the high-or moderate-quality evidence.Sclerotherapy was cost-effective and simple to operate,which was a main treatment plan or an auxiliary method during surgery.Absolute ethanol combined with lauromacrogol was effective and safe in the treatment of venous malformations and others.A total of 107 clinical trials were obtained,including the safety evaluation of sclerotherapy assisting surgery(39 cases,36.45%),the exploration of new sclerosants and safety and efficacy evaluation of existing sclerosants(61 cases,57.01%),the effect evaluation of the combination of sclerosants(seven cases,6.54%).The combined use of sclerosants was more effective than their single use,and foam sclerotherapy was effective and safe.Conclusion There are many kinds of sclerosants.It is suggested that domestic clinical physicians and pharmacists should comprehensively and systematically summarize the types and usage of sclerosants,and formulate standardized guidelines to better guide the clinical practice.
国家科技期刊平台
NSTL
万方数据
