Stability Study of Fat Emulsion,Amino Acids(17)and Glucose(11%)Injection
Objective To provide a basis for the rational use of Fat Emulsion,Amino Acids(17)and Glucose(11%)Injection(trade name:Kabiven PI)in clinical practice.Methods The liquid in three chambers of Kabiven PI was mixed evenly(sample S1)and added electrolytes(potassium chloride and sodium chloride,sample S2),vitamins(water-soluble vitamins and fat-soluble vitamins,sample S3),multiple trace elements(sample S4)and all the above components(sample S5)separately.The above samples were placed at room temperature for 0,4,8 and 12 h,the pH,osmotic pressure,number of insoluble particles of the mixture were determined,and the particle size of the emulsion was explored.Results There was no significant change in the appearance of the samples S1-S5 after being placed at room temperature for 12 h,and the pH was in the range of 5.51 to 5.59.The osmotic pressure of samples S2-S5 was in the range of 934 to 972 mOsmol/kg,816 to 831 mOsmol/kg,810 to 835 mOsmol/kg,934 to 957 mOsmol/kg respectively.The change in the number of insoluble particles of the mixture was not obvious within 12 h.The particle size of the emulsion was in the range of 1 to 10 nm.Conclusion The addition of electrolytes,vitamins and multiple trace elements within the specified limits in the Kabiven PI has a little effect on the pH,insoluble particles and particle size of emulsion.However,the addition of electrolytes has a great effect on the osmotic pressure,which should be paid attention.
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