Clinical Study of Quzhuo Qingyuan Decoction Combined with Tripterygium Glycosides in the Adjuvant Treatment of Diabetic Nephropathy
Objective To investigate the clinical efficacy of Quzhuo Qingyuan Decoction combined with tripterygium glycoside in the adjuvant treatment of diabetic nephropathy(DN).Methods A total of 120 patients with DN admitted to the hospital from June 2021 to June 2023 were selected and divided into the control group and the observation group by the random number table method,with 60 cases in each group.The patients in the two groups were given basic treatments(diet control,glucose lowering,diuresis,diminution of swelling,blood-pressure control,blood-lipid regulation)and Tripterygium Glycoside Tablets orally after meals,on this basis,the patients in the observation group were treated with Quzhuo Qingyuan Decoction.Both groups were continuously treated for three courses with eight weeks as a course.Results The total effective rate in the observation group was 91.67%,which was significantly higher than 75.00%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome(including shortness of breath,fatigue,dysphoria with feverish sensation in chest,palms and soles,soreness and weakness of the waist and knees,lower limb edema)scores in the observation group were significantly lower than those in the control group(P<0.05);β2-microglobulin(β2-MG),blood urea nitrogen(BUN)and serum creatinine(SCr)levels were significantly lower than those in the control group(P<0.05);microtubule-associated protein 1 light chain 3(LC3-Ⅱ),nuclear factor-κB(NF-κB),NOD-like receptor thermal protein domain associated protein 3(NLRP3)expression levels were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions,alanine aminotransferase(ALT)level and white blood cell count(WBC)were similar between the two groups after treatment(P>0.05).Conclusion Quzhuo Qingyuan Decoction combined with Tripterygium Glycoside Tablets in the adjuvant treatment of DN can improve the TCM syndrome,renal function,and reduce the inflammatory factors levels of patients.
diabetic nephropathyQuzhuo Qingyuan Decoctiontripterygium glycosideclinical efficacytraditional Chinese medicine syndromerenal function indexinflammatory factor
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