Clinical Study of Semaglutide Combined with Conventional Regimen in the Treatment of Diabetes Mellitus Type 2 Complicated with Carotid Atherosclerosis
Objective To investigate the clinical efficacy of semaglutide combined with conventional regimen in the treatment of diabetes mellitus type 2(T2DM)complicated with carotid atherosclerosis.Methods A total of 68 patients with T2DM and carotid atherosclerosis admitted to hospital from October 2021 to August 2022 were selected and randomly divided into the control group and the observation group,with 34 cases in each group.The patients in the two groups were given a conventional treatment regimen(oral hypoglycemic drugs,Atorvastatin Calcium Tablets),on this basis,the patients in the observation group were given the subcutaneous injection of Semaglutide Injection.Both groups were treated continuously for six months.Results After treatment,the body mass,body mass index(BMI),blood glucose indexes[fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPG),glycated hemoglobin(HbA1c)]levels,blood lipid indexes[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]levels,carotid intima-media thickness(IMT)and maximum plaque-sectional area(Smax)in the observation group were significantly better(P<0.05),the LDL-C,HDL-C levels and Smax were similar to those in the control group(P>0.05),while the others were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(14.71%vs.20.59%,P>0.05).Conclusion Semaglutide combined with conventional regimen in the treatment of T2DM complicated with carotid atherosclerosis can effectively control the patients'body mass,BMI,blood glucose and blood lipid levels,and improve the carotid plaques.
semaglutidediabetes mellitus type 2carotid atherosclerosisblood glucoseblood lipidbody masscarotid plaque
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