Analysis of Potentially Inappropriate Medication in Elderly Patients with Hypertension and Cerebral Infarction Based on Beers Criteria in a Hospital
Objective To ensure the medication safety of elderly patients with hypertension and cerebral infarction.Methods The medication orders of elderly patients(≥65 years)with hypertension and cerebral infarction were extracted by the hospital information system in 2020.The occurence of potentially inappropriate medication(PIM)in patients was analyzed by the American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults(hereinafter referred to as the Beers Criteria),and the independent risk factors for PIM were analyzed by the multivariate Logistic regression analysis.Results A total of 115 patients were included,of which 109 patients(94.78%)had PIM,involving 334 cases.The incidence of PIM related to careless medication in elderly patients was the highest(180 cases,53.89%),followed by drug-related PIM(121 cases,36.23%).Aspirin Enteric-Coated Tablets(78 cases,23.35%),Furosemide(31 cases,9.28%),Spironolactone Tablets(29 cases,8.68%)were related to a high frequency of PIM.Twenty-one cases of PIM were related to disease or symptoms,of which 95.23%cases had a history of renal insufficiency.Twelve cases of PIM involved drug interactions,mainly including the combination of nonsteroidal anti-inflammatory drugs and corticosteroids,the combination of two renin-angiotensin system(RAS)inhibitors,the combination of one RAS inhibitor and potassium sparing diuretics.Multivariate Logistic regression analysis showed that only medication>nine varieties was the independent risk factor for PIM in patients[OR = 10.056,95%CI(3.053,33.117),P<0.001].Conclusion The incidence of PIM in elderly patients with hypertension and cerebral infarction is high,and it is suggested that pharmacists should determine medication safety risks based on the Beers Criteria and clinical practice.
Beers Criteriahypertensioncerebral infarctionelderly patientpotentially inappropriate medicationpharmaceutical care
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