Application of Hepatoprotective Drugs for Patients with Chronic Hepatitis B
Objective To provide a reference for the rational use of hepatoprotective drugs in the clinic.Methods The consumption sum,defined daily dose system(DDDs),defined daily cost(DDC)and drug utilization index(DUI)of hepatoprotective drugs were analyzed,and the liver function of CHB patients who had at least two monitoring records of liver function serological indicators using a fixed hepatoprotective drugs regimen during the monitoring period with regular dosing were analyzed retrospectively.The univariate analysis was conducted on the factors affecting liver function indicators in CHB patients,and the Logistic regressions analysis was conducted on univariate analysis results with statistical significance.Results The top three hepatoprotective drugs in terms of the consumption sum and DDDs were Diammonium Glycyrrhizinate Enteric-Coated Capsules,Ursodeoxycholic Acid Capsules,and Bicyclol Tablets(25 mg).The top three drugs in terms of DDC were Ursodeoxycholic Acid Capsules,Bicyclol Tablets(25 mg),Bicyclol Tablets(50 mg).The DUI of all the hepatoprotective drugs did not exceed 1,and 37.31%(288/772)of CHB patients had at least two monitoring records of liver function serological indicators who used a fixed hepatoprotective drugs regimen during the monitoring period with regular dosing.The results of the univariate analysis showed that age<40 years old,abnormal levels of alanine aminotransferase(ALT)or aspartate aminotransferase(AST),taking medication regimens containing Bicyclol Alcohol Tablets had a significant impact on liver function indicators in CHB patients(P<0.05).The results of the Logistic regressions analysis showed that patients with abnormal ALT levels had better improvement in liver function(P<0.05).Conclusion The application of hepatoprotective drugs in the infection department of the hospital was relatively reasonable.More attention should be paid clinically to the medication regimens of hepatoprotective drugs for CHB patients with normal ALT,and drug supervision should be strengthened to ensure clinical efficacy.
万方数据
维普
