Trends and Hotspots in the Research on Drug-Induced Liver Injury in Children:A Bibliometric Analysis
Objective To investigate the distribution characteristics,development status,and trend hotspots of the research on drug-induced liver injury(DILI)in children,and to compare those with the overall research on DILI to provide a reference for the research of DILI in children.Methods The Web of Science database was searched for collecting DILI-related literature in children and DILI-related literature published from January 1,1999 and March 22,2023.Citespace 6.1R6 Advance software was used to visualize and analyze the number of publications,countries/regions,institutions,and keywords of DILI in children and DILI-related literature.Results A total of 18 757 relevant studies were retrieved,and 4 640 studies were ultimately included,including 334 studies of DILI in children and 4 306 studies of DILI.The visualization analysis results showed that the overall number of published studies related to DILI showed a stable upward trend,while the number of published studies related to DILI in children was fluctuating with no obvious development momentum.The United States of American(USA)and China rank first and second in terms of the number of publications,and the research institutions were mainly related to foreign universities,hospitals,and functional supervision institutions.The keyword analysis of DILI studies focused on pathogenesis,related comorbidities,diagnosis and treatment evaluation,risk prediction,disease management,and it was gradually combined with emerging data processing and analysis technologies.The studies on DILI in children was more focused on basic research on DILI-related risks,with a trend towards risk management.Conclusion It is recommended to innovate DILI research models,emphasize and conduct in-depth researches on the mechanisms,risk prediction,and disease management of DILI in children.
drug-induced liver injury in childrendrug-induced liver injurybibliometricsvisualization analysis
万方数据
维普
