Determination of Seven Elemental Impurities in Triethyl Citrate by ICP-MS
Objective To establish an inductively-coupled plasma-mass spectrometry(ICP-MS)method for the determination of residual quantity of seven elemental impurities[cadmium(Cd),lead(Pb),arsenic(As),mercury(Hg),cobalt(Co),vanadium(V),and nickel(Ni)]in triethyl citrate.Methods The online internal standard method was used,with helium as the carrier gas and HMI-8 plasma mode.The flow rates of the carrier gas,atomization gas,and auxiliary gas were all 0.8 L/min,the flow rate of plasma gas was 15.0 L/min,the speed of nebulizer pum was 0.10 r/min,and the temperature of atomizer chamber was 2℃.Results The linear ranges of V,Co,Ni,As,Cd,and Pb elements were 0-20.0 ng/mL,and the linear range of Hg element was 0-5.0ng/mL(r≥0.999 5,n = 7).The RSD of precision test result was lower than 3%(n = 6).The recovery rates of V,Co,Ni,As,Cd,Pb and Hg were 97.58%,96.12%,96.56%,100.25%,96.63%,99.80%,and 106.73%,with RSDs of 1.11%,1.29%,2.43%,1.09%,0.89%,1.26%,and 4.48%(n = 9),respectively.The content of seven elemental impurities in 23 batches of samples was lower than the control threshold.Conclusion This method is simple,has good precision,and accurate results,which can be used for the determination of trace elemental impurities in triethyl citrate.
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