Clinical Observation of Edaravone Dexborneol in the Treatment of Acute Cerebral Infarction
Objective To investigate the effect of edaravone dexborneol combined with tirofiban on Toll-like receptor 4(TLR4),nuclear factor-κB(NF-κB),and inflammatory cytokine levels in patients with acute cerebral infarction.Methods A total of 140 patients with acute cerebral infarction admitted to the Neurology Department of the hospital from June 2021 to December 2022 were selected and randomly divided into groups A,B,C,D by the random number table method,with 35 cases in each group.All patients were given conventional treatment,on this basis,the patients in group A were treated with aspirin.On the basis of group A,the patients in groups B,C,D were treated with tirofiban combined with edaravone dexborneol,tirofiban,and edaravone dexborneol,respectively.All four groups were treated for 14 d and followed up for three months.Results Compared with those in groups A,C,and D,the TLR4 and NF-κB levels in group B significantly decreased(P<0.05),the blood flow velocity of the anterior cerebral artery(ACA)in group B significantly decreased,the blood flow velocity of the middle cerebral artery(MAC)in group B significantly increased(P<0.05),while the hypersensitive C-reactive protein(hs-CRP)and neutrophil/lymphocyte ratio(NLR)in group B significantly decreased(P<0.05);the National Institutes of Health Stroke Scale(NIHSS)score and the Moeifiet Rankin Scale(mRS)score in group B significantly decreased,while the Bathel score in group B significantly increased after three months of treatment(P<0.05).The incidence rates of adverse reactions in groups A,B,C,and D were 14.29%,17.14%,11.43%and 8.57%respectively,without significant difference(P>0.05).Conclusion Edaravone dexborneol combined with tirofiban in the treatment of patients with acute cerebral infarction can improve the therapeutic effect,inhibit TLR4/NF-κB signal transduction,reduce levels of inflammatory factors,promote the recovery of cerebral blood flow and neurological function,and it has good safety.
万方数据
维普
