Clinical Observation of Modified Qinggan Huashi Huoxue Decoction Combined with Yinzhihuang Granules in the Treatment of Alcoholic Liver Disease
Objective To investigate the clinical efficacy of modified Qinggan Huashi Huoxue Decoction combined with Yinzhihuang Granules in the treatment of alcoholic liver disease.Methods A total of 200 patients with alcoholic liver disease admitted to the hospital from March 2021 to March 2023 were selected and randomly divided into the observation group and the control group by the random number table method,with 100 cases in each group.The patients in the two groups were given basic treatment for alcoholic liver disease.On this basis,the patients in the control group were treated with Yinzhihuang Granules,while the patients in the observation group were treated with Yinzhihuang Granules combined with modified Qinggan Huashi Huoxue Decoction.Both groups were treated for 12 weeks.Results The total effective rate in the observation group was 91.00%,which was significantly higher than 79.00%in the control group(P<0.05).After treatment,the scores of traditional Chinese medicine(TCM)syndromes such as rib pain,fullness,firm lumps,fatigue and numbness,and tongue redness and yellow coating in the observation group were significantly lower than those in the control group(P<0.05);the levels of alanine aminotransferase(ALT),glutamic oxalic aminotransferase(GST),alkaline phosphatase(ALP)and total bilirubin(TBiL)in the observation group were significantly lower than those in the control group(P<0.05);the maximum velocity(Vmax),average velocity(Vmea)and pulse index(PI)of hepatic portal vein in the observation group were significantly higher than those in the control group(P<0.05),while the resistance index(RI)in the observation group was significantly lower than that in the control group(P<0.05);the levels of inflammatory cytokines interleukin-17A(IL-17A),prostaglandin E2(PGE2)and CXC chemokine ligand 13(CXCL13)in the observation group were significantly lower than those in the control group(P<0.05);the scores of physical function,role function,social function,and overall health in the European Organization for Research and Treatment of Cancer(EORTC)Quality of Life Questionnare-Core 30(EORTC QLQ-C30)in the observation group were significantly higher than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions in the observation group was comparable to that in the control group(12.00%vs.8.00%,P>0.05).Conclusion Modified Qinggan Huashi Huoxue Decoction combined with Yinzhihuang Granules have good clinical efficacy and safety in the treatment of alcoholic liver disease,which can improve the TCM syndrome scores,liver function,and hepatic portal vein hemodynamic indexes,and reduce the level of inflammatory factors of patients.
alcoholic liver diseaseYinzhihuang GranulesQinggan Huashi Huoxue Decoctionclinical efficacytraditional Chinese medicine syndromeliver functionhepatic portal vein hemodynamicsinflammatory factors
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维普
