Clinical Observation of Paricalcitol Combined with Cinacalcet in the Treatment of Hyperparathyroidism
Objective To investigate the clinical efficacy of paricalcitol combined with cinacalcet in the treatment of hyperparathyroidism.Methods A total of 70 patients with hyperparathyroidism admitted to the hospital from January 2021 to August 2022 were selected and randomly divided into the control group and the observation group by the random envelope method,with 35 cases in each group.The patients in the two groups were treated with cinacalcet,while the patients in the observation group were treated with paricalcitol.Both groups were treated for six months.Results The total effective rate in the observation group was 97.14%,which was significantly higher than 74.29%in the control group(P<0.05).After treatment,the pain score,parathyroid volume,and parathyroid hormone levels in the two groups were significantly lower than those before treatment(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions in the observation group was comparable to that in the control group(14.29%vs.2.86%,P>0.05).Conclusion Paricalcitol combined with cinacalcet is effective and safe in the treatment of hyperparathyroidism,which can alleviate the pain level of patients,and reduce the volume of parathyroid glands,and parathyroid hormone levels.
万方数据
维普
