Comparison of Efficacy and Safety of Original-Patented and Generic Amlodipine Besylate in the Treatment of Hypertension
Objective To compare the efficacy and safety of original-patented and generic amlodipine besylate in the treatment of hypertension.Methods A total of 243 patients who received original-patented amlodipine besylate and 272 patients who received generic amlodipine besylate for the treatment of hypertension in the First Affiliated Hospital of Xi'an Jiaotong University from January 1 to June 30,2021 were selected.Propensity matching analysis(1∶1)was used to match the original-patented group and the generic group,with 155 cases in each group.Both groups were continuously treated for three months.Results After treatment,the systolic blood pressure,diastolic blood pressure,and pulse pressure difference in the two groups significantly reduced(P<0.05),but the difference was not statistically significant(P>0.05).There was no statistically significant difference in clinical efficacy,excellent and good rate of medication compliance,and incidence of adverse reactions between the two groups(P>0.05).Conclusion Generic amclodiplain besylate has the same efficacy,medication compliance and safety as the original-patented amclodiplain besylate in the treatment of hypertension.
万方数据
维普
