Objective To analyze the clinical characteristics of meropenem-induced neutropenia,and to provide a reference for its safe use in the clinic.Methods A clinical pharmacist's participation in the treatment process of one case of meropenem-induced neutropenia was reviewed,and relevant literature on meropenem-induced neutropenia in databases such as CNKI,WanFang,VIP,PubMed,and MedSci were searched from their inception to February 10,2023.The clinical characteristics of meropenem-induced neutropenia were analyzed from the patient's demographic characteristics,usage and dosage of meropenem,occurrence time of neutropenia,severity and clinical manifestations of neutropenia,intervention,and outcome.Results A total of 5 801 studies were retrieved,and nine studies were included,involving nine patients.Among the ten patients included in the review(including one reported case in this study and nine literature search cases),there were six males and four females,five cases with the age less than or equal to three years old;all 10 patients had clear usage and dosage of meropenem;the primary diseases were mainly intracranial infections and bloodstream infections;the incubation period for adverse drug reactions was 8-20 d(with an average of 14.5 d);eight patients had severe neutropenia,and two patients had fever and rash.Neutrophil counts returned to normal in five patients after drug withdrawal,and in five patients after treatment with Human Granulocyte Stimulating Factor Injection to elevated leukocyte on the basis of drug withdrawal.One patient had an unknown specific recovery time due to lack of regular follow-up,while the average recovery time of the other nine patients was 6.9 d.Conclusion Meropenem-induced neutropenia is rare and reversible,with a long incubation period.Most patients have no obvious clinical manifestations,but the degree is serious.When meropenem is used clinically,the patient's neutrophil count should be closely monitored for timely detection and treatment,to ensure the medication safety of patients.
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