Literature Analysis of Adverse Drug Reactions Caused by Papaverine Hydrochloride Injection
Objective To analyze the general patterns and characteristics of adverse drug reactions(ADRs)caused by Papaverine Hydrochloride Injection,and to provide a reference for rational drug use in the clinic.Methods Taking"Papaverine"and"Adverse Drug Reactions"as the keywords,relevant literature related to ADRs caused by Papaverine Hydrochloride Injection in the CNKI and WanFang databases was searched from their inception of the databases to January 2023.The occurrence time,primary disease,administration route,clinical manifestations,and irrational use of ADRs were statistically analyzed.Results A total of 17 studies were retrieved,involving 23 patients and 33 cases of ADRs.Among them,the gender ratio of male to female was 6.67∶1,and 56.52%of patients were aged 45 and above;60.87%of patients had ADRs occurring within 10-30 min and 1-2 d after medication;the administration routes were intravenous infusion(39.13%),intramuscular injection(21.74%),and intracavernous injection of the penis(21.74%);the main primary diseases were insufficient blood supply to the vertebral artery(17.39%),fractures(13.04%),angina(13.04%),erectile dysfunction(13.04%),and myocardial ischemia(13.04%);the most affected systems/organs were the skin and appendages disorders(7 cases,21.21%),heart rate disorders and arrhythmia(5 cases,15.15%),male reproductive disorders(5 cases,15.15%),urinary system damage(4 cases,12.12%),and gastrointestinal system damage(4 cases,12.12%);the main clinical manifestations were urinary retention,priapism,multiform tachycardia ventricular,anaphylactic shock,bullous epidermolysis,atrophy-necrosis drug eruption.Conclusion ADRs of Papaverine Hydrochloride Injection affect multiple tissues and organs in the human body,and the clinical manifestations are diverse.Clinical attention should be paid to the ADRs caused by Papaverine Hydrochloride Injection,and medication monitoring should be strengthened to ensure medication safety.
papaverineadverse drug reactionsliterature analysis
万方数据
维普
