Application of Wilm's Tumor Gene1 Peptide Vaccine Galinpepimut-S in Tumor Immunotherapy
Objective To provide a reference for the follow-up research of Wilm's tumor gene1(WT1)peptide vaccine Galinpepimut-S(GPS)for tumor immunotherapy.Methods Tumor immunotherapy-related literature in the CNKI and PubMed databases were searched from the inception to December,and the application of GPS in tumor treatment was summarized.Results GPS can stimulate the autoimmune system to produce a strong immune response to WT1 antigen,and play an anticancer role.It has shown good therapeutic effects in the treatment of ovarian cancer,malignant pleural mesothelioma,acute myeloid leukemia,and multiple myeloma.It has shown good therapeutic effects in ovarian cancer,malignant pleural mesothelioma,acute myeloid leukemia,and multiple myeloma.Conclusion The cancer vaccine represented by GPS is an important direction for future cancer treatment,and further clinical research is needed to obtain more data.
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