Preliminary Study on Pharmacodynamics of Fuzheng Bixie Granules with Different Prescriptions
Objective To investigate preliminarily the pharmacodynamics of Fuzheng Bixie Granules with different prescriptions.Methods The sample A without volatile oils and sample B with volatile oils were prepared.The acute toxic effects of the above two samples on mice were observed by the maximum dose method.The anti-inflammatory,immunomodulatory and antipyretic effects of the above two samples were explored by the xylene-induced ear swelling model in mice,cyclophosphamide-induced hypoimmunity model in mice,and lipopolysaccharide(LPS)-induced fever model in rats,respectively.Results The body weight of mice in each group increased naturally,the body weight and major organ coefficients in different sample groups were similar to those in the control group(P>0.05).The results of three model tests were as follows:the ear swelling degree of mice in the samples A and B low-dose groups was significantly lower than that in the model group one(P<0.05);the ear swelling degree in the all groups with drugs was similar to that in the model group two(P>0.05);the anal temperature change after mtraperitoneal injection of LPS for 3.0 h in the sample A low-dose group,after mtraperitoneal injection of LPS for 0.5 h,1.0 h and 3.0 h in the sample B low-dose group and after mtraperitoneal injection of LPS for 1.0 h in the sample B high-dose group was significantly different from that in the model group three(P<0.05).Conclusion Fuzheng Bixie Granules have anti-inflammatory,immunomodulatory and antipyretic pharmacological effects.Compared with the prescriptions with only extracts,the prescriptions with extracts and volatile oils are more effective.
Fuzheng Bixie Granulesvolatile oilacute toxicity testanti-inflammationimmunomodulatoryantipyreticextraction process
万方数据
维普
