Exploration of Prescription Medication Rules in Case Reports of Amyotrophic Lateral Sclerosis
Objective To provide a reference for the clinical treatment of amyotrophic lateral sclerosis(ALS)with traditional Chinese medicine.Methods Case reports of Chinese materia medica in the treatment of ALS in the CNKI from the inception of this database to November 2022 were searched.The medicinal frequency of use,nature,flavor,meridian returned and efficacy in prescriptions were recorded by the Excel software and imported into the Traditional Chinese Medicine Inheritance Computer System(V 3.0)for data mining.Results A total of 110 case reports were included,involving 139 prescriptions and 218 Chinese materia medicas,with the cumulative use frequency of 1 946 times.Forty-five Chinese materia medicas were commonly used,with a frequency of use>10%,the nature,flavor and meridian returned was mainly warm(47.35%),sweet(42.45%)and spleen meridian(20.29%),and the efficacy was mainly tonifying deficiency(41.37%).There were 98 drug combinations,involving 24 Chinese materia medicas,mainly Astragali Radix-Atractylodis Macrocephalae Rhizoma-Codonopsis Radix(33 times),with the main drug pairs of Astragali Radix-Dioscoreae Rhizoma(32 times)and Astragali Radix-Rehmanniae Radix Praeparata(32 times).The cluster analysis showed that five core drug combinations were extracted.Conclusion The deficiency-tonifying drugs are the core in the medication prescriptions for ALS in case reports,including Qi-,blood-,Yang-,liver-and kidney-tonifying drugs,and they are supplemented with Yang-lifting,interior-warming and Qi-moving drugs.The prescription combination are mainly based on the principles of tonifying Qi and blood,tonifying Yin and Yang,clearing heat and dissipating phlegm,and benefiting Qi and activating blood.
amyotrophic lateral sclerosisTraditional Chinese Medicine Inheritance Computer Systemcase reporttonifying deficiencyChinese materia medicamedication rule
万方数据
维普
