Objective To investigate the risk factors for vancomycin-associated acute kidney injury(VA-AKI)and failure to recover renal function in patients with VA-AKI.Methods Clinical data of patients treated with vancomycin in the hospital from January 2017 to December 2022 were collected,the incidence of VA-AKI and therapeutic drug monitoring(TDM)was analyzed.Univariate analysis and multivariate Logistic regression analysis were used to evaluate the risk factors for VA-AKI and failure to recover renal function in patients respectively.Results A total of 158 patients were included,43 of whom(27.22%)had VA-AKI,and 145 patients required TDM,61 of whom(42.07%)underwent it.The multivariate Logistic regression analysis showed that complication with heart disease[OR = 0.036,95%CI(0.004,0.308),P = 0.002],complication with tumors[OR = 0.103,95%CI(0.012,0.910),P = 0.041],surgery[OR = 0.060,95%CI(0.011,0.324),P = 0.001]and combination with loop diuretics[OR = 0.090,95%CI(0.022,0.378),P = 0.001]were the independent risk factors for VA-AKI in patients.VA-AKI stage three[OR = 24.788,95%CI(2.567,239.343),P = 0.006]was the independent risk factors for failure to recover renal function in patients with VA-AKI.Conclusion Complication with heart disease,tumors,surgery and combination with loop diuretics are the independent risk factors for VA-AKI in patients,and VA-AKI stages three is the independent risk factor for failure to recover renal function in patients.
关键词
万古霉素/急性肾损伤/危险因素/肾功能恢复/Logistic回归分析
Key words
vancomycin/acute kidney injury/risk factor/renal function recovery/Logistic regression analysis
维普
万方数据