目的 为临床应用泽泻活性成分防治非酒精性脂肪性肝病(NAFLD)提供参考。方法 采用计算机检索中国知网(CNKI)和PubMed数据库中泽泻活性成分改善NAFLD的相关研究及临床应用的相关文献，检索时限为自建库起至 2023 年 8 月，从药理学作用总结泽泻活性成分改善NAFLD的作用机制，并探讨其临床应用的可行性。结果 泽泻活性成分Alisol A 24-acetate，Alisol B 23-acetate，Alisol F，Alismol，Alisol A，Alisol B可通过改善胰岛素抵抗、改善脂质代谢、调控胆固醇稳态、抗氧化应激反应、抗炎、调节肠道菌群等方面来改善NAFLD。泽泻复方制剂用于治疗NAFLD的疗效良好，尤其联用其他中药可进一步增强疗效。结论 泽泻及其活性成分有防治NAFLD的潜力，但需要更多临床研究证实其安全性、有效性及作用机制。
Research Progress on the Mechanism of Active Ingredients from Alismatis Rhizoma in the Improvement of Non-Alcoholic Fatty Liver Disease
Objective To provide a reference for the clinical application of active ingredients from Alismatis Rhizoma in the prevention and treatment of non-alcoholic fatty liver disease(NAFLD).Methods The literature related to the study and clinical application of active ingredients from Alismatis Rhizoma in the improvement of NAFLD in the CNKI and PubMed were searched from the inception of the database to August 2023.According to the pharmacological effects,the mechanism of active ingredients from Alismatis Rhizoma in improving NAFLD was summarized,and the feasibility of their clinical application was explored.Results The active ingredients from Alismatis Rhizoma such as Alisol A 24-acetate,Alisol B 23-acetate,Alisol F,Alismol,Alisol A and Alisol B can improve NAFLD by improving insulin resistance,enhancing lipid metabolism,regulating cholesterol homeostasis,promoting anti-oxidant reaction and anti-inflammatory,and regulating intestinal flora.Alismatis Rhizoma compound oreparations are effective in the treatment of NAFLD,especially when they were combined with other traditional Chinese medicine can further enhance the therapeutic effect.Conclusion Alismatis Rhizoma and its active ingredients show significant potential in the prevention and treatment of NAFLD,but more clinical studies are needed to confirm their safety,efficacy,and mechanism.
万方数据
维普
