Retrospective Analysis of 966 New and Severe Adverse Drug Reactions
Objective To promote medication safety in the clinic.Methods The reports submitted by Rizhao City,Shandong Province from November 2021 to November 2022 to the National National Adverse Drug Reaction(ADR)Monitoring System,which have been evaluated and identified as new and severe ADR reports were searched.Retrospective analysis was conducted on patients′ gender and age,administration route,drug classification,involved organs/systems and clinical manifestations,outcomes,and occupations of reporting personnel in the reports by the Excel software.Results A total of 4 545 cases of ADRs were reported,including 966 new and severe ADR reports(21.25%),with more females than males(55.80%vs.44.20%),and the most number of ADRs accurred in elderly patients over 60 years old(49.90%).The main administration route was intravenous infusion(58.28%).ADR involved 424 drugs,mainly induced by anti-infective drugs(26.50%),anti-tumor drugs(19.67%),and traditional Chinese medicine preparations(17.08%),involving 75 kinds of drugs(17.69%),47 kinds of drugs(11.08%),and 111 kinds of drugs(26.18%),respectively.The clinical manifestations mainly involved the digestive system(24.12%),systemic damage(20.44%),skin and accessories(17.60%),and blood system(14.10%),with the main outcome being improvement(55.07%)or recovery(40.48%).The reporting personnel were mainly physicians(92.86%).Conclusion Medical institutions should strengthen the monitoring and reporting of ADRs of clinical medication in patients,especially elderly patients,in order to timely find and handle them correctly and improve medication safety.
new adverse drug reactionssevere adverse drug reactionsmedication safetypharmacovigilance
万方数据
维普
