Effect of Different Doses of Esmketamine on Postpartum Depression and Pain Level After Cesarean Section
Objective To investigate the effects of different doses of esketamine on postpartum depression(PPD)and pain level after cesarean section.Methods A total of 330 postpartum women who underwent cesarean section in the Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University from October 2021 to October 2022 were selected and divided into the control group,the low-dose group,and the high-dose group by the random number table method,with 110 cases in each group.After cesarean section,patient-controlled intravenous analgesia(PCIA)was performed.The three groups were given the regimen of sufentanil(50 μg),butorphanol tartrate(10 mg),and ondansetron(8 mg),on this basis,the low-dose group was given 0.6 mg/kg of esketamine,while the high-dose group was given 1.2 mg/kg of esketamine,and the drugs in the three groups were diluted to 100 mL with 0.9%Sodium Chloride Injection.Results Compared with those in the control group,the Edinburgh Postnatal Depression Scale(EPDS)scores in the low-dose and high-dose groups significantly reduced at 3 d and 7 d after surgery(P<0.05),the visual analogue scale(VAS)scores at rest and activity significantly reduced at 4 h,12 h,24 h,and 48 h after surgery(P<0.05),and those in the high-dose group were significantly lower than those in the low-dose group(P<0.05).There was a significant difference in the incidence of PPD among the high-dose group,low-dose group,and control group at 3 d and 7 d after surgery(4.55%vs.8.18%vs.14.55%,6.36%vs.10.91%vs.18.18%,P<0.05).The incidence of adverse reactions among the three groups was comparable(P>0.05).Conclusion High-dose esketamine can effectively reduce the PPD score and incidence of depression after cesarean section,alleviate the degree of pain after cesarean section,and it has good safety.
万方数据
维普
