Postoperative Efficacy and Influencing Factors of Qianlie Shutong Capsules Combined with Solifenacin in the Treatment of Elderly Patients with Benign Prostatic Hyperplasia Complicated with Overactive Bladder
Objective To investigate the postoperative efficacy of Qianlie Shutong Capsules combined with Solifenacin in the treatment of elderly patients with benign prostatic hyperplasia(BPH)complicated with overactive bladder(OAB),and to analyze the relevant factors affecting the efficacy.Methods A total of 102 elderly patients with BPH complicated with OAB admitted to the Urology Department of the hospital from March 2020 to March 2023 were retrospectively selected and divided into the control group(49 cases)and the observation group(53 cases)according to different treatment medication regimens.The patients in the two groups were orally administered Solifenacin Succinate Tablets,on this basis,the patients in the observation group were treated with Qianlie Shutong Capsules.Both groups were treated continuously for two months.The total effective rate,maximum urinary flow rate(Qmax),postvoid residual urine(PVR),International Prostate Symptom Score(IPSS),Quality of Life Scale for Benign Prostatic Hyperplasia(BPHQOL),and Symptom of Overactive Bladder Symptom Scale(OABSS)in two groups were compared.One-way analysis of variance(ANOVA)was used to identify the relevant factors affecting the postoperative efficacy of Qianlie Shutong Capsules in elderly patients with BPH complicated with OAB,and multivariate Logistic regression analysis was used to identify independent risk factors of the relevant factors.Results The total effective rate in the observation group was 90.57%,which was significantly higher than 71.43%in the control group(P<0.05).After treatment,the Qmax significantly increased,while the PVR,IPSS score,BPHQOL score,and OABSS score significantly decreased in the two groups(P<0.001),and those in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was comparable to that in the control group(32.08%vs.40.82%,P>0.05).The results of one-way ANOVA showed that preoperative IPSS score,OABSS score,prostate volume,PVR,and intraoperative bleeding were relevant factors affecting the efficacy of Qianlie Shutong Capsules(P<0.05).Multivariate Logistic regression analysis showed that prostate volume,preoperative IPSS score,and PVR were independent risk factors(P<0.05).Conclusion Qianlie Shutong Capsules combined with solifenacin have good clinical efficacy in the treatment of postoperative elderly patients with BPH complicated with OAB,and can effectively improve the quality of life.The patient′s prostate volume,preoperative IPSS score,and PVR have certain predictive value for clinical efficacy of elderly patients with BPH complicated with OAB.
万方数据
维普
