Efficacy and Safety of Kunbao Pills in the Treatment of Menopausal Syndrome:A Meta-Analysis
Objective To systematically review the efficacy and safety of Kunbao Pills in the treatment of menopausal syndrome.Methods Relevant studies in the PubMed,Embase,The Cochrane Library,Web of Science,CNKI,WanFang,and VIP databases from the inception to December 2022 were searched.Two evaluators independently screened the literature,extracted data,and evaluated the risk of bias in the included studies.Meta-analysis was performed by the RevMan 5.3 software.Results A total of 13 studies including 1 590 patients(803 patients in the observation group and 787 patients in the control group)with menopausal syndrome,and subgroup analysis was conducted according to the type of drugs in the control group.The clinical efficacy in the Kunbao Pills monotherapy group was significantly higher than that in the flunarizine + glutathione + vitamin B1 group[RR = 1.75,95%CI(1.38,2.22),P<0.000 01].The clinical efficacy in the Kunbao Pills combination group was significantly higher than that in the estradiol valerate + medroxyprogesterone acetate group[RR = 1.18,95%CI(1.03,1.34),P = 0.01],and that in the Ciwujia group[RR = 1.20,95%CI(1.08,1.33),P = 0.000 7].The Kupperman score in the Kunbao Pills monotherapy group was significantly lower than that in the Tibolone group[MD =-6.00,95%CI(-7.72,-4.28),P<0.000 01].The follicle-stimulating hormone[MD =-25.70,95%CI(-33.22,-18.18),P<0.000 01]and luteinizing hormone[MD =-11.20,95%CI(-12.05,-10.35),P<0.000 01]in the Kunbao Pills combination group were significantly lower than those in the Ciwujia group.The estradiol(E2)level in the Kunbao Pills monotherapy group was significantly higher than that in the Tibolone group[MD =-7.00,95%CI(-11.44,-2.56),P = 0.002].The main adverse reactions were abdominal bloating,constipation,dizziness,vaginal bleeding,weight gain,etc.,which were all tolerated by the patients.Conclusion Compared with hormone therapy,Kunbao Pills in the treatment of patients with menopausal syndrome have comparable or even better clinical efficacy,Kupperman score,and hormone index improvement.However,due to the low-quality of the included studies,more rigorous and high-quality clinical studies are needed for further confirmation.
万方数据
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