Establishment and Application of Criteria for Drug Utilization Evaluation of Low-Molecular-Weight Heparin Injection Based on Attribute Hierarchy Model and Weighted TOPSIS Method
Objective To promote the clinical rational use of low-molecular-weight heparin(LMWH)injection.Methods Based on the drug instructions(involving daheparin,nadroparin calcium,enoxaparin sodium),relevant guidelines and literature,a drug utilization evaluation(DUE)criteria for LMWH injection was established by the Delphi method.A total of 300 medical records(100 for each of the above three LMWHs)of inpatients using LMWH injection in a tertiary hospital from January to July 2023 were extracted,and the rationality of drug use was evaluated by the technique for order preference by similarity to ideal solution(TOPSIS)method.Results The medical records with the similarity coefficient of evaluation indicator to ideal solution(Ci)≥80%(rational)accounted for 16.00%,70%≤Ci<80%(basically rational)accounted for 44.00%,60%≤Ci<70%(basically rational)accounted for 39.00%,Ci<60%(irrational)accounted for 1.00%.The mean Ci of daheparin,nadroparin calcium and enoxaparin sodium were(79.19±0.12)%,(72.62±0.10)%,(76.22±0.10)%respectively,with a significant difference between the groups(F = 9.016,P<0.001);there were one,two,zero medical records with irrational medication respectively;the irrational problems mainly were inappropriate indications,inappropriate timing and dosage of administration,incomplete laboratory examination and lack of monitoring and reporting of adverse reactions.Conclusion The criteria and methods established in this study can be used to evaluate the rationality of clinical use of LMWHs.
国家科技期刊平台
NSTL
万方数据
维普
