Investigation and Analysis of Drug-Drug Interactions in Comprehensive Management of Diabetes Mellitus
Objective To analyze the characteristics and influencing factors of drug-drug interactions(DDIs)in comprehensive management of diabetes mellitus(DM).Methods The Lexi-InteractTM database was used to screen DDIs of hypoglycemic,antihypertensive,blood lipid-regulation and weight-loss drugs in the comprehensive management of DM.Based on the severity,the DDIs were divided into the grade X(avoiding combined use),grade D(considering adjusting treatment),grade C(requiring monitoring treatment),grade B(not requiring adjustment),grade A(without DDI).The data of patients with diabetes mellitus type 2(T2DM)and myocardial infarction in a tertiary-A hospital in Shanghai were collected,the patients were divided into the low-DDIs group(<five cases of DDIs)and high-DDIs group(≥five cases of DDIs),the characteristics and influencing factors of DDIs were analyzed.Results A total of 109 drugs were included,including 57,32,19,one antihypertensive,hypoglycemic,blood lipid-regulation and weight-loss drugs,with 5 091,1 086,723,15 cases of DDIs respectively.Except for weight-loss drugs,the other three drugs with the most cases of DDIs were calcium channel blockers(CCBs),sulfonylureas,statins,respectively.The top three drugs of grade X with many cases of DDIs were statins,CCBs and β receptor antagonists.A total of 69 patients were included,with 26 in the low-DDIs group and 43 in the high-DDIs group,respectively.The risk factors affecting the cases of DDIs in patients included the number of combined medications,chronic kidney disease(CKD)of stages one to three,glycated hemoglobin,glycated albumin and fasting blood glucose(P<0.05).Conclusion Rational number of combined medications and normal blood glucose level are beneficial to reduce the DDIs in the comprehensive management of DM.
diabetes mellituscomprehensive managementhypoglycemicregulation of blood lipidantihypertensivebody massdrug-drug interactionrisk factor
国家科技期刊平台
NSTL
万方数据
维普
