Research Progress on the Biological Activity,Extraction and Purification Processes of Mussel Polysaccharides
Objective To provide a reference for the research of extraction process and clinical application of mussel polysaccharides.Methods The relevant literature in the VIP,CNKI,and PubMed from January 1995 to September 2023 were searched to summarize the biological activities,extraction and purification processes of mussel polysaccharides,and compare the differences in mussel polysaccharide extracts under different extraction and purification process parameters.Results The mussel polysaccharides had immune-regulation,anti-tumor,analgesic,anti-inflammatory,anti-hepatitis B virus and liver-protection biological activities.The mussel polysaccharides were mostly extracted based on the hot water extraction(80-100℃),assisted by microwave or ultrasound extraction methods,but the process parameters were greatly different;most of the crude extracts were obtained by alcohol precipitation;after purification of mussel polysaccharides,there were some differences in the monosaccharide composition(glucose accounting for a large proportion)and molecular weight(400-1 700 kDa).Conclusion It is necessary to strengthen the research on the extraction process-pharmacodynamic relationship,the structure-activity relationship of active ingredients,the chemical modification-pharmacodynamic relationship of mussel polysaccharides to lay the foundation for the development of relevant drugs and functional foods.
国家科技期刊平台
NSTL
万方数据
维普
