Comparison of Common Opioids Metabolized by CYP450 Enzymes
Objective To summarize the cytochrome P450(CYP450)enzyme metabolism processes involved in common opioid drugs such as oxycodone,methadone,tramadol,and buprenorphine.Methods PubMed was searched from its inception to March 2024 for studies on the metabolism of opioids such as oxycodone,methadone,tramadol and buprenorphine via the CYP450 enzyme,as well as drug-drug interactions involved in the CYP450 enzyme.Results CYP450 enzyme was the most important enzyme in the metabolism of opioid drugs such as oxycodone,methadone,tramadol,and buprenorphine.CYP3A4 and CYP2D6 were not only involved in the metabolism of most opioid but also a large number of other drugs,and opioid drugs were prone to have drug-drug interactions with other drugs during the medication.Conclusion Knowledge of the metabolism of opioids in the liver,and the overlapping pharmacodynamics and pharmacokinetics involved in drug-drug interactions can help to circumvent possible adverse drug reactions during the medication.
opioidscytochrome P450 enzymemetabolismadverse drug reactionsdrug-drug interactions
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