Law Analysis of Anti-Epidemic Prescriptions Containing Bupleuri Radix in the Dictionary of Traditional Chinese Medicine Prescriptions and Research on the Mechanism of Core Drug Pair in the Treatment of COVID-19
Objective To predict the potential target and mechanism of Bupleuri Radix in the treatment of COVID-19.Methods The anti-epidemic prescriptions containing Bupleuri Radix were collected from the Dictionary of Traditional Chinese Medicine Prescriptions,and the frequency statistics,association rules,cluster analysis,and other data mining on their compatibility and treatment of diseases were conducted by SPSS Statistics 25 software.Chemical components and COVID-19 targets of Bupleuri Radix-Scutellariae Radix were selected through database and literature search,and the"component-target-pathway"network was constructed through Cytoscape 3.9.0.Results A total of 442 anti-epidemic prescriptions containing Bupleuri Radix were collected,involving 334 traditional Chinese medicines(TCM),with a total frequency of 4 877 times.The network pharmacological results showed that there were 80 targets for the intersection of the active ingredients of Bupleuri Radix-Scutellariae Radix.The main components of Bupleuri Radix-Scutellariae Radix in the treatment of COVID-19 were kaempferol,baicalin,berberine,wogonin and robinin,and core active genes such as epidermal growth factor receptor(EGFR),signal transduction and transcription activating factor 3(STAT3),serine/threonine protein kinase 1(AKT1),and interleukin-2(IL-2).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis obtained 3 736 related items and 230 signaling pathways,mainly including the EGFR signaling pathway,hypoxia-inducible factor-1(HIF-1)signaling pathway,tumor necrosis factor(TNF)signaling pathway,vascular endothelial growth factor(VEGF)signaling pathway,and nuclear factor κB(NF-κB)signal pathways,etc.Conclusion Bupleuri Radix-Scutellariae Radix drug pair has a mechanism of multi-component,multi-target and multi-pathway in the prevention and treatment of COVID-19,which is of great significance for guiding the rational TCM clinical application of Bupleuri Radix,the development of Bupleuri Radix in the disease prevention and treatment,and the research and development of new TCM for epidemic prevention.
Bupleuri RadixScutellariae RadixDictionary of Traditional Chinese Medicine Prescriptionsdata miningnetwork pharmacologyrule of formulationCOVID-19
万方数据
维普
