Efficacy of Different Doses of Tirofiban Combined with Nimodipine in the Treatment of Patients Undergoing Interventional Surgery for Intracranial Aneurysms
Objective To investigate the efficacy of different doses of tirofiban combined with nimodipine in the treatment of patients undergoing interventional surgery for intracranial aneurysms.Methods A total of 100 patients who underwent interventional surgery for intracranial aneurysms in the Hengshui People's Hospital from January 2020 to January 2023 were selected and randomly divided into group A and group B,with 50 patients in each group.The patients in the two groups were given interventional therapy,anticoagulant,and antiplatelet regimens.After stent implantation,the patients in group A immediately received full-dose of tirofiban[intravenous injection of tirofiban at a loading dose of 10 μg/kg for 3 min,maintained infusion at 0.15 μg/(kg·min)],while the patients in group B immediately received half-dose of tirofiban[intravenous injection of tirofibanat a loading dose of 5 μg/kg for 3 min,maintained infusion at 0.075 μg/(kg·min)].All patients received nimodipine 48 h later.Results The incidence rates of ischemic and hemorrhagic complications in group A were comparable to those in group B(8.00%vs.6.00%,6.00%vs.0,P>0.05).The degree of immediate postoperative embolism in group B was significantly better than that in group A(P<0.05).There was no significant difference in the levels of thrombin time(TT),prothrombin time(PT),activated-partial thromboplastin time(APTT),and fibrinogen(FIB)between the two groups before and 24 h after surgery(P>0.05).The clinical prognosis and mortality rate in group A and group B at discharge were comparable(78.00%vs.88.00%,6.00%vs.2.00%,P>0.05).The incidence of adverse reactions in group A was comparable to that in group B(20.00%vs.10.00%,P = 0.161>0.05).Conclusion Intravenous injection of full-dose and half-dose of tirofiban combined with nimodipine is safe and effective in the treatment of patients undergoing interventional surgery for intracranial aneurysms,with comparable incidence of perioperative complications,coagulation indicators,prognosis,and incidence of adverse drug reactions.However,half-dose of tirofiban has a better preventive effect on perioperative embolism.
tirofibannimodipineinterventional surgery for intracranial aneurysmrisk of thrombus
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